Simplicef Tablets

Simplicef Tablets

This treatment applies to the following species:

(cefpodoxime proxetil)

For Oral Use In Dogs Only

Simplicef Tablets Caution

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Description

Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic cephalosporin antibiotic. The chemical name is:

(+ / - ) - 1 - Hydroxyethyl(+) - (6R,7R) - 7 - [2 - (2 - amino - 4 - thiazolyl)glyoxylamido] - 3 - methoxymethyl) - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - ene - 2 - carboxylate, 7 2 -(Z)-(0-methyloxime), isopropyl carbonate (ester) [87239-81-4].

Cefpodoxime proxetil Chemical Structure:

Cefpodoxime proxetil is a prodrug, its active metabolite is cefpodoxime. All doses of SIMPLICEF (cefpodoxime proxetil) tablets are expressed in terms of the active cefpodoxime moiety. SIMPLICEF is available as:

100 mg Tablet, each reddish-orange, elliptical, scored tablet contains cefpodoxime proxetil equivalent to 100 mg of cefpodoxime.

200 mg Tablet, each light orange, round rectangle, scored tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime.

Simplicef Tablets Indication

SIMPLICEF tablets are indicated for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius. Staphylococcus aureus. Streptococcus canis (group G, β, hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.

Simplicef Tablets Dosage And Administration

Dose range: The dose range of SIMPLICEF (cefpodoxime proxetil) tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient’,s host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.

Duration: SIMPLICEF tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.

Dosing Charts: For daily oral administration of SIMPLICEF at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).

Table 1. Dose Table for SIMPLICEF Tablets at 5 mg/kg Total Daily Dosage

Weight of Dog (lbs)

Source