Diphenhydramine hcl

Diphenhydramine Hydrochloride

Rx ONLY

Diphenhydramine Description

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(diphenylmethoxy)-N,N -dimethylethylamine hydrochloride and has the molecular formula C 17 H 21 NO&bull,HCI (molecular weight 291.82). It occurs as a white odorless, crystalline powder and is freely soluble in water and alcohol. The structural formula is as follows:

Always get your pet's drug and dose recommendation from the veterinarian.

Each 5 mL contains 12.5 mg of Diphenhydramine hydrochloride and alcohol 14% for oral administration.

Inactive Ingredients:

Citric acid, D&,C Red No. 33, FD&,C Red No. 40, flavoring, purified water, sodium citrate, and sucrose.

Diphenhydramine - Clinical Pharmacology

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

A single oral dose of Diphenhydramine hydrochloride is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of Diphenhydramine hydrochloride is from four to six hours. Diphenhydramine is widely distributed throughout the body, including the CNS. Little, if any, is excreted unchanged in the urine, most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

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